threonine – Communicable Diseases Research

Reveal the Mechanisms of Yi-Fei-Jian-Pi-Tang on Covid-19 through Network Pharmacology Approach

네트워크 약리학 접근법을 통해 Covid-19에 대한 Yi-Fei-Jian-Pi-Tang의 메커니즘 공개

Article

Published on 2022-07-162022-09-11
Journal: Computational Intelligence and Neuroscience
[Category] 유전자 메커니즘,

Proteomic and Metabolomic Signatures Associated With the Immune Response in Healthy Individuals Immunized With an Inactivated SARS-CoV-2 Vaccine

비활성화된 SARS-CoV-2 백신으로 면역된 건강한 개인의 면역 반응과 관련된 단백질 및 대사체 서명

Article

Published on 2022-05-242022-09-11
Journal: Frontiers in Immunology
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] Activation Adaptive immune response adaptive immune system affected Amino acid amino acids Analysis applied approach Arm Biosynthesis Cohort complement Complement activation CoronaVac COVID-19 dose driving glycine help highlight host response humoral Humoral response identify IgM/IgG immune immune response immune response. immune signature Immunity immunization immunized Inactivated vaccine individual innate immune system Interaction mechanism metabolic pathway metabolic pathways metabolism metabolite metabolites metabolomics molecular molecular mechanism multifactorial network Phenylalanine proteomics proteomics. response SARS-CoV-2 SARS-COV-2 infection Serine shown signature Sinovac specific IgM Systems biology TCA cycle threonine Tryptophan tyrosine utility vaccination Volunteer
[DOI] 10.3389/fimmu.2022.848961 PMC 바로가기 [Article Type] Article

The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway

칸디다 알비 칸스 CDK8- 의존적 포스 포 단백체는 FLO8- 의존적 경로를 통한 균사 성장의 억압을 나타낸다.

Research Article

Published on 2022-01-042022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] acquisition activities Affect Amino acid amino acids analyses ATP Candida Candida albican Candida albicans Cdk8 cell interactions cellular conditions dead dependent on drug resistance functional growth hypha hyphal identify Immune cell Impact inactivation increased expression inhibited Interaction interactions involved leads mediator Mediator complex medium member metabolism modulate Morphological morphological changes morphology mutant Mutation nutrient pathway performed phenotype Phenotypes phosphoproteome phosphorylation site physiological promoted Protein Protein phosphorylation sites Rapid reduced regulate Regulation regulator replaced reveal Serine shown Steady state strain substrate target targets the strongest These data threonine Transcription transcription factor transcriptional transcriptomics variant virulence was used
[DOI] 10.1371/journal.pgen.1009622 PMC 바로가기 [Article Type] Research Article

Association of Complement and MAPK Activation With SARS-CoV-2–Associated Myocardial Inflammation

SARS-CoV-2–관련 심근 염증과 보체 및 MAPK 활성화의 연관성

Research

Published on 2021-12-152022-09-10
Journal: JAMA Cardiology
[Category] MERS, SARS, 유전자 메커니즘,

[키워드] abundance age Analysis assessment biopsies C1q capture capture sequencing cardiac Cardiomyopathy cascade case sery CD163 center Characteristics characterized clade Cohort cohort of patients collected complement Complement cascade component confirmation cysteine Endomyocardial biopsy Ethnicity Exome exploratory exposure Factor finding Future Germany highest histologic Hospitalized immune pathway immune signature Immune-mediated implication Importance individual Infection Inflammatory inflammatory condition inflammatory conditions inhibitor Injury kinases lymphocyte Lymphocyte count lymphocyte counts Macrophage macrophages male MAPK mass mass spectrometry Maximilian measure median age mitogen mitogen-activated protein kinase Munich Myocardial inflammation myocardial injury myocarditis objective participant Participants pathway Pathways Patient patients with SARS-CoV-2 phenotype Point Protein protein kinase protein kinases proteinase Proteins proteomic Proteomic analysis reduce Referral Relevance Result RNA SARS-COV-2 infection Sequencing Serine setting signaling cascade similarities specimen specimens subunit the median threonine tissue transcript transcriptomic transcriptomic analysis Treatment strategies treatment strategy Tübingen university upregulated upregulation Viral viral myocarditis were measured
[DOI] 10.1001/jamacardio.2021.5133 PMC 바로가기 [Article Type] Research

SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation

SARS-CoV-2는 바이러스 전파를 촉진하기 위해 RIPK1 활성화를 촉진합니다

Article

Published on 2021-10-182022-09-11
Journal: Cell Research
[Category] MERS, SARS, 바이오마커, 변종, 유전자 메커니즘, 치료기술,

[키워드] ACE2 activate Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid amino acid substitution blocked caused Cell Biology cell death cells CNS conserved Coronaviral coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cytokine Cytokine storm Cytokines death downregulated EGFR Evidence evidence of examined facilitate Factor global pandemic Host host defense host defense response human lung organoid human lung organoids Inflammation inhibition inhibitor Innate immunity Interaction Italy lead lombardy lung lung viral load Mechanisms of disease mediator Mortality Nsp12 Proinflammatory cytokine proinflammatory cytokines promote promoted public health reduced Replication respiratory RIPK1 RNA-dependent RNA polymerase SARS-CoV-2 SARS-COV-2 infection Serine severe acute respiratory syndrome Coronavirus subset systemic inflammatory response the SARS-CoV-2 therapeutic therapeutic option threonine Transcription transcriptional transgenic mice Treatment treatment of COVID-19 variant Viral viral entry Viral load viral propagation
[DOI] 10.1038/s41422-021-00578-7 PMC 바로가기 [Article Type] Article

The Role of the PFNA Operon of Bifidobacteria in the Recognition of Host’s Immune Signals: Prospects for the Use of the FN3 Protein in the Treatment of COVID-19

숙주의 면역 신호 인식에서 비피도박테리아의 PFNA 오페론의 역할: COVID-19 치료에서 FN3 단백질의 사용에 대한 전망

Review

Published on 2021-08-262022-09-10
Journal: International Journal of Molecular Sciences
[Category] MERS, SARS, 유전자 메커니즘,

Nodosome Inhibition as a Novel Broad-Spectrum Antiviral Strategy against Arboviruses, Enteroviruses, and SARS-CoV-2

아르보바이러스, 엔테로바이러스 및 SARS-CoV-2에 대한 새로운 광범위한 항바이러스 전략으로서의 Nodosome 억제

Article

Published on 2021-07-162022-09-11
Journal: Antimicrobial Agents and Chemotherapy
[Category] SARS, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alphaviruses Antiviral antiviral activity Antiviral effect arbovirus Arboviruses Brain broad spectrum broad-spectrum antiviral broad-spectrum antivirals causative agent Cell coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 coxsackievirus downstream drug enhancement expression fetal function Host induce Infection inhibit inhibition inhibitor interferon interferon response NOD2 nodosome. novel nucleotide observation oligomerization pathogenic promote Protein protein kinase Replication RIPK2 RNA viruses SARS-CoV-2 Serine severe acute respiratory syndrome Coronavirus shown small molecule Spread Strategy target the interferon threonine Zika virus ZIKV
[DOI] 10.1128/AAC.00491-21 PMC 바로가기 [Article Type] Article

Computational Mutagenesis at the SARS-CoV-2 Spike Protein/Angiotensin-Converting Enzyme 2 Binding Interface: Comparison with Experimental Evidence

SARS-CoV-2 스파이크 단백질/안지오텐신 전환 효소 2 결합 인터페이스에서의 전산 돌연변이 유발: 실험 증거와의 비교

Article

Published on 2021-03-182022-09-10
Journal: ACS Nano
[Category] 변종,

[키워드] ACE2 ACE2 residue acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amino acid amino acids angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 antiviral therapeutics arginine aspartic acid binding caused cellular China computational mutagenesis contribute coronavirus coronavirus disease coronavirus disease-2019 COVID-19 D30E dimension dimensions Effect Emergency use authorization ENhance free energy of binding glutamic acid glycoprotein human host hydrophobic in silico inhibitor interface residue Invasion isoleucine lysine molecular molecular dynamics molecular mechanics/Poisson−Boltzmann surface area (MM/PBSA) mutant Neutralizing antibodies neutralizing antibody pandemic pathogen polar predicted Prevent promote Protein Protein binding receptor binding domain Receptor binding domain Recognition regimen replaced REPLACED BY residue residues respiratory resulting S-protein S-RBD SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 spike protein Serine severe acute respiratory syndrome Coronavirus shape spike spike glycoprotein Spread strength the SARS-CoV-2 therapeutic threonine treat Tryptophan Vaccine variant variants Variation Viral viral spike wild-type yielding
[DOI] 10.1021/acsnano.0c10833 PMC 바로가기 [Article Type] Article

Causal network models of SARS-CoV-2 expression and aging to identify candidates for drug repurposing

약물 용도 변경 후보를 식별하기 위한 SARS-CoV-2 발현 및 노화의 인과 관계 네트워크 모델

Article

Published on 2021-02-152022-08-31
Journal: Nature Communications
[Category] MERS, 신약개발, 유전자 메커니즘, 치료제,

[키워드] Analysis approach approved drug candidate candidate drugs Causal clinical trial clinical trials Critical Data integration data-driven Diseases Drug discovery Drug repurposing expression Gene regulatory networks High-throughput screening highlight identify in vitro experiment kinase kinases lung lung epithelium machine learning pandemic pathogenicity Pathways platform Protein target protein targets proteomic RNA-seq data robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic Serine severity suggested target the SARS-CoV-2 threonine transcriptional transcriptomic tyrosine Virtual drug screening while
[DOI] 10.1038/s41467-021-21056-z PMC 바로가기 [Article Type] Article

Phage infection and sub-lethal antibiotic exposure mediate Enterococcus faecalis type VII secretion system dependent inhibition of bystander bacteria

파지 감염 및 준치사 항생제 노출은 Enterococcus faecalis type VII 분비 시스템 의존적 방관자 억제 억제를 매개합니다.

Research Article

Published on 2021-01-072022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] abrogate activated addition Affect antagonism antibacterial activity antibiotic Antibiotics Bacteria Bacterial bacterial cell bacterial cells Bacterial infections bacterial pathogen bacteriophage bacteriophages bacterium bystander Cell cells clinically Concentration Consensus consequence Contact Deletion Disruption DNA damage DNA damaging dose Enterococcus Evidence evidence of expression facilitate Gene Expression gram growth highlight Host Immunity independent independent of induce Infection Interaction intrinsic killing membrane microbial Microbial communities multi-drug resistant multidrug resistant pathogen phage phages positive predicted respond restrict resulting secretion Serine Staphylococcus aureus Stress stress response Stressor susceptible therapeutic therapy These data threonine Transcription transcription factor Treatment Trigger triggering triggers upstream
[DOI] 10.1371/journal.pgen.1009204 PMC 바로가기 [Article Type] Research Article